Mouse Study Data on Oral-Gut Microbiota and Systemic Effects of High-Fat Diet

Male C57BL/6J mice were assigned to standard chow or high-fat diet groups and monitored until 4, 12, and 18 months of age. The dataset includes measurements of body weight, glucose-lipid metabolism, liver function, blood markers, behavioral tests, and 16S rRNA sequencing results from oral and fecal samples. It was authored by Yixue Tian and last updated on March 18, 2026.

Use Cases

• Identify microbial biomarkers for obesity based on 16S rRNA sequencing data from oral and gut samples.
• Analyze correlations between specific bacterial genera (e.g., Romboutsia_B) and systemic health parameters like blood lipids and cognitive performance.
• Model the longitudinal effects of a high-fat diet on metabolic and behavioral outcomes across different age groups in mice.
• Investigate the functional pathways of the oral-gut-liver-brain axis using predicted metagenomic and short-chain fatty acid profiling data.

Strengths

• Data includes longitudinal measurements across three distinct age groups (young, middle-aged, old).
• Multimodal assessment combines physiological, metabolic, behavioral, and microbial sequencing data.
• Analysis identifies a specific microbial genus, Romboutsia_B, as a potential biomarker with detailed correlation results.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• Data is from an animal model (C57BL/6J mice), which may limit direct translation to human biology.

Provenance

Source

figshare, authored by Yixue Tian.

Collection Method

Experimental data from a controlled animal study involving diet manipulation, physiological measurements, behavioral tests, and 16S rRNA sequencing.

Time Range

Study duration until mice reached 4, 12, and 18 months of age.

Freshness

Last updated 2026-03-18 07:41:36; freshness should be verified.