Roundup® Effects on Thyroid Cancer Cell Viability and Proliferation

Experimental data from a comparative study on glyphosate-based herbicide effects in thyroid carcinoma cells. The dataset, authored by Izabela Fernanda Dal’ Bó and shared under CC-BY-4.0, was last updated in April 2026. It likely contains measurements of cell viability and proliferation for different human thyroid cell lines exposed to varying concentrations of Roundup®.

Use Cases

• Analyzing dose-response relationships for glyphosate-based herbicides based on concentration ranges mentioned in the description.
• Comparing cell-type-specific sensitivity to environmental contaminants based on the hierarchy of sensitivity established for different thyroid cancer lines.
• Investigating non-monotonic or biphasic proliferative effects in cancer models based on the described transient responses.
• Assessing potential tumor-promoting roles of low-dose chemical exposures based on the reported proliferative stimulation at environmentally relevant concentrations.

Strengths

• Data is integrated from multiple cell lines (BCPAP, 8505C, Nthy 3-1, TPC-1) for comparative analysis.
• Exposure concentrations are specified across a defined range (6.5–6500 µg/L) and include a dose below regulatory limits (65 µg/L).
• Experimental outcomes are clearly defined, including cell viability and proliferation measured at 24 and 48 hours.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The dataset is very small (193.7 KB), indicating limited scope.

Provenance

Source

figshare

Collection Method

Laboratory experiments using trypan blue exclusion, CCK-8, and BrdU incorporation assays on human thyroid cell lines.

Time Range

Experimental timeframe not specified; dataset metadata updated 2026.

Freshness

Last updated 2026-04-23 04:21:38; freshness should be verified.

Geography

Laboratory study; geographic origin not specified.