RUNX1/miR-24/ALK4 Axis Data for Hepatic Stellate Cell Activation and Liver Fibrosis

Zhijing Wang's research data, last updated in 2026, investigates the role of miR-24 in liver fibrosis. The dataset includes results from qRT-PCR, Western blotting, luciferase assays, and clinical serum analysis from patients with liver cirrhosis. It is shared under a CC-BY-4.0 license on figshare.

Use Cases

• Validate miR-24 as a biomarker for liver fibrosis screening based on clinical serum level correlations.
• Model the RUNX1/miR-24/ALK4 signaling pathway based on described gene expression and protein interaction data.
• Train classifiers to predict HSC activation states based on molecular profiles described in the study.
• Correlate miR-24 expression levels with disease progression stages like Child–Pugh grade as indicated in the clinical results.

Strengths

• Includes clinical data from patients with liver cirrhosis and healthy controls.
• Mechanistic validation uses multiple experimental methods (qRT-PCR, Western blot, luciferase assays, ChIP-PCR).
• Clear biological conclusion identifying the RUNX1/miR-24/ALK4 axis.

Limitations

• Dataset is a single 811.7 KB DOCX file; the underlying structured data (e.g., raw numerical results) is not directly accessible.
• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.

Provenance

Source

Zhijing Wang via figshare.

Collection Method

Experimental data from in vitro HSC studies, animal models (CCl4-induced fibrosis), and human serum samples.

Freshness

Last updated 2026-04-29 22:02:13; freshness should be verified.