SBSPON Gene Association with Type 2 Diabetes and Telomere Length in Northwest India

672.8 KB research document details a candidate gene association study for Type 2 Diabetes Mellitus (T2DM). Itty Sethi authored this CC-BY-4.0 licensed study, last updated in April 2026, which investigates the SBSPON gene's expression, the variant rs2291219, and its relationship with leukocyte telomere length in a Northwest Indian population.

Use Cases

• Validate the association of the SBSPON gene variant rs2291219 with T2DM risk based on the reported p-value and odds ratio.
• Investigate the relationship between genetic risk alleles and leukocyte telomere length attrition mentioned in the results.
• Design replication studies in other populations based on the findings from the Northwest Indian cohort.
• Perform in silico functional analysis of genetic variants as described in the study's methodology.

Strengths

• Study reports specific statistical findings, including a p-value of 0.02 and an odds ratio of 1.48 for the gene variant association.
• Research includes multiple analysis methods: gene expression, TaqMan genotyping, and in silico functional prediction.
• Data is openly shared under a CC-BY-4.0 license, facilitating reuse.

Limitations

• The primary data file is a 672.8 KB DOCX document; the underlying raw or processed tabular data is not directly provided.
• Row count and column-level documentation are absent, which may limit suitability assessment for direct computational analysis.
• The dataset's scale is limited to a single case-control study in a specific geographic population.

Provenance

Source

figshare, authored by Itty Sethi.

Collection Method

Case-control candidate gene association study employing gene expression analysis, TaqMan genotyping, and in silico methods.

Time Range

null

Freshness

Last updated 2026-04-16 04:20:24

Geography

Northwest Indian population.