Sea Buckthorn Seed Oil Antifungal Mechanism Against Aspergillus Niger

A 331.3 KB document by Yanhua Xin, last updated April 2026, details the antifungal mechanism of sea buckthorn seed oil against Aspergillus niger. The study employed an integrated approach combining network pharmacology, transcriptomics, molecular docking, and molecular dynamics simulations. It identified seven key bioactive compounds and 26 potential targets, with transcriptomics revealing 580 differentially expressed genes.

Use Cases

• Identify potential antifungal drug targets based on the 26 targets identified via network pharmacology.
• Study gene expression changes in fungal pathogens based on the 580 differentially expressed genes revealed by transcriptomics.
• Validate compound-target interactions for drug discovery based on molecular docking and dynamics simulations against MAPK3 and BCL2.
• Investigate mitochondrial dysfunction pathways in fungi based on experimental results showing reduced membrane potential and elevated ROS.
• Explore the AGE-RAGE-like signaling pathway in fungal stress response as suggested by the study's conclusions.

Strengths

• The study integrates multiple methodologies: network pharmacology, transcriptomics, molecular docking, and molecular dynamics simulations.
• Specific quantitative results are reported, including 7 bioactive compounds, 26 targets, and 580 differentially expressed genes.
• Includes in vitro experimental validation of key findings related to mitochondrial function and oxidative stress.

Limitations

• The dataset is a 331.3 KB DOCX file, which is a small document rather than a structured data repository.
• Row count and column-level documentation are absent; the file contains research narrative rather than tabular data.
• Freshness should be verified as the last update date is in the future (2026-04-21).

Provenance

Source

figshare, author Yanhua Xin

Collection Method

Integrated research combining computational and experimental biology techniques.

Freshness

Last updated 2026-04-21 05:34:31; freshness should be verified.