Seasonal Lipid and Homocysteine Changes in Coronary Heart Disease Patients

A retrospective paired study analyzes seasonal variation in lipid profiles and homocysteine for patients with and without coronary heart disease (CHD) in a cold-climate region. The study compares within-individual differences between summer and winter measurements over a three-year period at a single center. It quantifies seasonal changes as Δ (Winter − Summer) and identifies heterogeneous response patterns between CHD and non-CHD groups.

Use Cases

• Compare seasonal Δ (Winter − Summer) values for LDL-C, total cholesterol, triglycerides, and homocysteine between CHD and non-CHD patient groups.
• Assess the heterogeneity of seasonal response patterns using statistical significance (p-values) reported for triglycerides and HDL-C.
• Analyze the magnitude of seasonal effects on lipid biomarkers, characterized as small in the effect size analyses.
• Investigate the attenuated seasonal variation and directionally altered responses, such as lower HDL-C tendency, specific to the CHD patient cohort.

Strengths

• Data collection spans a three-year period, allowing for seasonal comparison.
• Study design is a paired retrospective analysis, enabling within-individual assessment of summer versus winter measurements.
• Focus on a specific cold-climate region provides contextual relevance for seasonal cardiovascular research.

Limitations

• Dataset scope is limited to a single center, which may reduce generalizability.
• The study concludes seasonal differences are modest with small effect sizes, limiting predictive power.
• Data is presented in a 390.6 KB PDF, requiring extraction for computational analysis.

Provenance

Source

Tao Liu via figshare.

Collection Method

Retrospective, paired study using first-time measurements of lipid profiles and homocysteine from patient records.

Time Range

Three-year period (specific years not stated).

Freshness

Last updated 2026-03 25.

Geography

Single center in a cold-climate region.