Research Paper on Lithocholic Acid Effects in a Human Colitis-on-Chip Model

A 9.6 MB PDF research paper authored by Tim Kaden and last updated in May 2026. The paper investigates the protective role of the secondary bile acid lithocholic acid in a dextran sodium sulfate-induced colitis model using a human intestine-on-chip system. It reports that lithocholic acid treatment ameliorated colitis-like inflammation by stimulating epithelial cell proliferation and activating the farnesoid X receptor.

Use Cases

• Analyzing the relationship between bile acid levels and intestinal inflammation based on the described colitis-on-chip model.
• Studying the mechanism of farnesoid X receptor activation in maintaining intestinal barrier integrity as described in the paper.
• Investigating the use of human organ-on-chip systems for recapitulating physiological disease responses mentioned in the research.

Strengths

• File size is 9.6 MB, indicating a complete document.
• License is CC-BY-4.0, permitting broad reuse with attribution.
• Last update date is 2026-05 08, suggesting recent availability.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The dataset is a single PDF document, not structured data for direct computational analysis.

Provenance

Source

figshare

Collection Method

Likely contains experimental data and analysis from a research study using a human intestine-on-chip system.

Time Range

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Freshness

Last updated 2026-05-08 05:48:15; freshness should be verified.

Geography

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