Secretory VSMC-derived THBS1 Promotes Macrophage M1 Polarization

24 KB of bioinformatic and experimental validation data supporting a THBS1-CD47 signaling axis in intracranial aneurysms. The dataset likely contains results from bulk transcriptomic (GSE54083) and single-cell RNA-seq (GSE193533) analyses, weighted gene co-expression network analysis (WGCNA), and CellChat predictions. Author Jianhuang Huang published the data on figshare under a CC-BY-4.0 license in April 2026.

Use Cases

• Validate predicted ligand-receptor interactions based on CellChat algorithm results
• Analyze gene expression patterns associated with macrophage M1 polarization based on transcriptomic data
• Investigate correlations between THBS1 levels and inflammatory cytokine expression based on in vitro co-culture experiments
• Study the enrichment of M1-like macrophages and phenotypically switched VSMCs based on bioinformatic analyses

Strengths

• Data integrates findings from two distinct gene expression datasets (GSE54083 and GSE193533)
• Includes validation from in vitro experiments using HA-VSMCs and THP-1-derived macrophages
• Published under a permissive CC-BY-4.0 license

Limitations

• Column-level documentation is absent; field semantics must be inferred after download
• Row count is unknown, which may limit suitability assessment
• Data may reflect methodological bias inherent to the specific bioinformatic and experimental techniques described

Provenance

Source

figshare

Collection Method

Analysis of public transcriptomic datasets (GSE54083, GSE193533) combined with in vitro cell culture experiments.

Freshness

Last updated 2026-04-10 06:00:27; freshness should be verified