Pediatric IBD Study on Segmented Filamentous Bacteria and Disease Activity

A cross-sectional study analyzes 60 pediatric subjects, including 30 with inflammatory bowel disease (IBD) and 30 controls with functional gastrointestinal disorders. It examines the association between segmented filamentous bacteria (SFB) positivity and disease activity indices like PCDAI and PUCAI, along with inflammatory markers such as fecal calprotectin and C-reactive protein. The data originates from a clinical study by Yuling Feng, published on figshare in 2026.

Use Cases

• Analyze the association between SFB positivity status and disease activity indices (PCDAI, PUCAI) across patient subgroups.
• Compare inflammatory marker levels (fecal calprotectin, C-reactive protein, erythrocyte sedimentation rate) between SFB-positive and SFB-negative IBD patients.
• Investigate SFB positivity rates across patient stratification groups: Untreated Active (UTA), Treated Remission (TRR), and Treated Active (TRA).
• Examine differences in SFB positivity between disease types (Crohn's disease and ulcerative colitis) within the pediatric IBD cohort.

Strengths

• Clinical data from a controlled study with 60 pediatric subjects (30 IBD patients and 30 controls).
• Analysis includes multiple validated clinical metrics: disease activity indices (PCDAI, PUCAI) and inflammatory markers (fecal calprotectin, CRP, ESR).
• Clear subgroup stratification (UTA, TRR, TRA) and disease type classification for comparative analysis.

Limitations

• Small sample size of 60 total subjects limits statistical power and generalizability of findings.
• Data is presented in a PDF report (305.1 KB), requiring extraction for computational analysis; underlying tabular data is not directly provided.
• Cross-sectional design captures a single time point, preventing analysis of causal relationships or longitudinal trends.

Provenance

Source

figshare, authored by Yuling Feng.

Collection Method

Clinical cross-sectional study; SFB detected via polymerase chain reaction from ileal lavage fluid.

Freshness

Last updated on 2026-03-24.