Case Report: Severe Pembrolizumab-Induced Autoimmune Hemolytic Anemia with Novel Treatment

A single clinical case report authored by Qin Ye, published on figshare in 2026. The document describes a 52-year-old female patient with anal canal melanoma who developed severe autoimmune hemolytic anemia after treatment with the PD-1 inhibitor pembrolizumab. It details the patient's clinical presentation, diagnosis, and a novel immunosuppressive treatment strategy involving cyclophosphamide and fluorouracil.

Use Cases

• Analyze clinical presentation patterns of severe immunotherapy-related adverse events based on the described symptoms and lab results.
• Study treatment strategies for steroid-refractory autoimmune hemolytic anemia based on the described combination of cyclophosphamide, fluorouracil, corticosteroids, and IVIG.
• Investigate the feasibility of immunotherapy rechallenge after a severe adverse event based on the patient's subsequent treatment course.
• Support educational material on rare hematologic complications of cancer immunotherapy based on the detailed case narrative.

Strengths

• Provides a detailed, peer-reviewed narrative of a rare and serious clinical event.
• Includes specific clinical data points such as patient age, drug regimen, lab values (LDH, bilirubin, Coombs test), and treatment timeline.
• Released under a permissive CC-BY-4.0 license, allowing for broad reuse and sharing.

Limitations

• Row count is unknown, which may limit suitability assessment; this is a single case report, not a dataset of multiple records.
• Column-level documentation is absent; the data is presented as unstructured text within a PDF, requiring manual extraction.
• The 45.0 KB file size indicates a very limited scope, containing only the text of the case report.

Provenance

Source

figshare, author Qin Ye.

Collection Method

Likely a documented clinical case from medical practice.

Time Range

The case timeline is described, but the overall dataset's temporal coverage is not specified.

Freshness

Last updated 2026-05-08 05:51:27; freshness should be verified.

Geography

The geographic origin of the case is not specified in the provided metadata.