Sex-Dependent Transcriptomic and Epigenomic Profiles of Neutrophils in COPD Patients

3.7 MB of integrated transcriptomic and epigenomic data from circulating neutrophils of male and female COPD patients, authored by Barbara Mariotti and last updated on 2026-05-27. The description indicates the data reveals sex-specific differences in inflammatory and autophagy-related pathways, with male neutrophils showing enrichment for interferon signaling and cytokine-mediated networks.

Use Cases

• Identify sex-specific gene expression signatures in COPD based on the described transcriptomic profiles.
• Analyze epigenetic regulation of inflammatory loci based on the reported H3K27ac enrichment data.
• Investigate correlations between neutrophil transcriptional programs and plasma inflammatory mediators like CXCL8 and TNF-α mentioned in the description.
• Compare disease-associated transcriptional frameworks between sexes as described in the results.

Strengths

• Data integrates both transcriptomic and epigenomic profiling from a specific cell type (neutrophils).
• Analysis is focused on a clinically relevant population (COPD patients) with a specific biological variable (sex).
• Dataset is openly available under a CC-BY-4.0 license.

Limitations

• The 3.7 MB size suggests a small-scale or summary dataset; raw sequencing data is likely not included.
• Column-level documentation and sample data are unavailable, requiring manual inspection after download.
• Row count is unknown, which may limit suitability assessment for certain analyses.

Provenance

Source

figshare, author Barbara Mariotti.

Collection Method

Transcriptomic and epigenomic profiling of circulating neutrophils from COPD patients.

Freshness

Last updated 2026-05-27 20:01:59; freshness should be verified.