Sex-Related Peripheral Immune Profile in Ulcerative Colitis: Links to Fatigue

Thyra Albrecht published a clinical study on 2026-05-14 involving 89 individuals (29 with active ulcerative colitis, 30 in remission, and 30 healthy controls). The dataset likely contains flow cytometry and cytokine measurements for immune cell subsets and plasma markers, alongside fatigue scores from the IBD-F questionnaire. The research explores sex-stratified correlations between peripheral immune dysregulation and fatigue severity in ulcerative colitis.

Use Cases

• Train models to predict fatigue severity based on immune cell subset profiles mentioned in the description.
• Analyze sex-specific correlations between immune biomarkers (e.g., TNF, BDNF, sTREM-2) and clinical symptoms.
• Investigate immune cell trafficking patterns via CD62L and CCR2 expression data across disease stages.
• Compare peripheral immune profiles (neutrophils, monocytes, dendritic cells, T cell subsets) between active disease, remission, and healthy controls.

Strengths

• Includes data from 89 individuals across three distinct clinical groups (active UC, remission, healthy controls).
• Measures multiple immune parameters: flow cytometry for cell subsets and plasma cytokines (BDNF, TNF, IL-6, IL-18, sTREM-2).
• Uses a validated fatigue assessment tool (the Inflammatory Bowel Disease Fatigue questionnaire).

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The dataset is small (53.9 KB), indicating limited scope.

Provenance

Source

figshare

Collection Method

Clinical study using flow cytometry, cytokine assays, and questionnaire data.

Freshness

Last updated 2026-05-14 04:27:22; freshness should be verified.