Rat Behavioral and Neurochemical Data Following Adolescent Polydrug Exposure

A 394.5 KB PDF from figshare by Philippe De Deurwaerdère, last updated April 2026, details a study on Long-Evans rats. The research investigates sex-specific behavioral and neurochemical changes from adolescent exposure to ethanol, WIN55,212-2, and nicotine. Data includes behavioral scores from hole-board and elevated plus maze tests and postmortem monoamine levels from brain regions like the prefrontal cortex and amygdala.

Use Cases

• Analyzing sex-specific behavioral alterations based on hole-board and elevated plus maze test results.
• Modeling functional connectivity in monoaminergic networks based on correlation analyses of serotonin, dopamine, and noradrenaline.
• Investigating long-term neuroadaptations based on data collected at postnatal days 30, 60, and 90.

Strengths

• Data includes longitudinal behavioral assessments at three time points (P30, P60, P90).
• Neurochemical analysis covers multiple brain regions (prefrontal cortex, amygdala, substantia nigra).
• Explicitly compares male and female subjects, enabling sex-difference analysis.
• Published under a permissive CC-BY-4.0 license.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The dataset is small (394.5 KB), indicating limited raw data scope.

Provenance

Source

figshare, author Philippe De Deurwaerdère.

Collection Method

Experimental data from a controlled animal study involving behavioral tests and postmortem neurochemical quantification.

Time Range

Study period covers rat development from postnatal day 30 to 90.

Freshness

Last updated 2026-04-10 05:58:07; freshness should be verified.

Geography

Laboratory study; geographic location is not specified.