Sex-Specific Hippocampal Microstructure in Adolescents with Mild TBI

4,399 adolescents from the ABCD Study were analyzed using restriction spectrum imaging to characterize hippocampal microstructural alterations following mild traumatic brain injury. The study, authored by Jiyoung Ma and published on figshare in May 2026, found sex-specific differences in hippocampal restricted normalized diffusion. These alterations were associated with verbal learning and memory performance on the Rey Auditory Verbal Learning Test.

Use Cases

• Investigating sex-specific neurodevelopmental responses to mild traumatic brain injury based on hippocampal microstructure.
• Analyzing associations between neuroimaging biomarkers and cognitive performance based on RAVLT scores.
• Modeling potential neuroplastic adaptations in adolescents based on diffusion imaging data.

Strengths

• Data is sourced from the large-scale Adolescent Brain Cognitive Development (ABCD) Study, involving 4,399 participants.
• Analysis includes sex-stratified results, highlighting a significant finding (Bonferroni-corrected p = 0.02) for male adolescents.
• Dataset is openly licensed under CC-BY-4.0.

Limitations

• The dataset is a 607.4 KB PDF, which is a small document rather than a raw data file.
• Column-level documentation and sample data are unavailable, requiring manual inspection after download.
• The cross-sectional design and retrospective parent report for mTBI history limit causal inference, as noted in the description.

Provenance

Source

Adolescent Brain Cognitive Development Study (ABCD Study®)

Collection Method

Restriction spectrum imaging (RSI) data analysis and retrospective parent report via the modified Ohio State University TBI Screen-Short Version.

Time Range

Data from adolescents aged 11–12 years.

Freshness

Last updated 2026-05-08 05:40:37.

Geography

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