Data Sheet 1_Shared immune dysregulation in systemic lupus erythematosus and colorectal ca

A research data sheet presents findings from an integrated multi-omics analysis of systemic lupus erythematosus and colorectal cancer cohorts. The study identifies 58 shared differentially expressed genes and a predictive model based on four hub genes (DNASE1L3, PTPN14, SELENBP1, ECRG4). It was authored by Hui Guan and last updated on March 18, 2026.

Use Cases

• Validate the identified shared gene signature (DNASE1L3, PTPN14, SELENBP1, ECRG4) for disease prediction models.
• Investigate immune infiltration patterns common to systemic lupus erythematosus and colorectal cancer based on the described multi-omics approach.
• Explore potential small-molecule drug candidates suggested by the shared dysregulation pathways.
• Study the role of DNASE1L3 in macrophage efferocytosis and polarization using the described cellular experimental framework.

Strengths

• Analysis integrates multiple public omics datasets (e.g., GSE61635, GSE39582, E-MTAB-8107) for cross-validation.
• Findings are supported by cellular experiments (RT-qPCR, flow cytometry) on THP-1 and NCM460 cell lines.
• The predictive model is based on four specific hub genes identified through machine learning.

Limitations

• The primary file is a 29.0 MB DOCX document, not a structured data table; underlying raw data is not directly provided.
• Column-level documentation and sample data are unavailable, requiring manual extraction of information from the text.
• Row count and the exact structure of any supplementary data are unknown.

Provenance

Source

figshare, author Hui Guan.

Collection Method

Integrated analysis of public gene expression and omics datasets, supplemented with original cellular experiments.

Freshness

Last updated 2026-03-18 07:38:17