Gastric Cancer and Depression Comorbidity: Shared Molecular Features and Pathways

130 gastric cancer-associated and 534 depression-associated genes were identified from public databases. The dataset includes six identified hub genes and associated miRNA-mRNA networks, validated via experimental methods. It was created by Bin Liu and last updated on 2026-05-20.

Use Cases

• Identify potential biomarker genes for gastric cancer-depression comorbidity based on the overlapping gene list.
• Analyze immune cell infiltration patterns associated with hub genes using single-sample Gene Set Enrichment Analysis.
• Investigate miRNA-mRNA regulatory networks targeting the identified hub genes like SERPINE1.
• Explore candidate pathways such as PI3K-Akt and AGE-RAGE for mechanistic studies linking gastric cancer and depression.

Strengths

• Includes 130 gastric cancer-associated and 534 depression-associated genes.
• Six hub genes were identified and validated via real-time quantitative PCR and Western blot.
• Analysis includes Gene Ontology, Kyoto Encyclopedia of Genes and Genomes, and protein-protein interaction network results.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The primary data file is an 8.5 MB PDF, which may require extraction of underlying data.

Provenance

Source

Gene Expression Omnibus, DisGeNET, and GeneCards databases.

Collection Method

Genes were identified via database mining and analyzed with bioinformatics and experimental validation.

Freshness

Last updated 2026-05-20 08:07:27; freshness should be verified.