Sheep Placental Extract Effects on PCOS in Rats: Transcriptomics and 16S rRNA Data

A 102.1 KB dataset uploaded on 2026-04-13 by Cunlin Zhang under a CC-BY-4.0 license. It contains results from a study where a PCOS model was induced in rats using letrozole, followed by treatment with sheep placental extract. The data likely includes measurements of inflammatory cytokines, sex steroid hormones, metabolic markers, transcriptomics, and 16S rRNA sequencing results.

Use Cases

• Analyze the relationship between Treg cell upregulation and ovarian histopathology based on the described anti-inflammatory effects.
• Investigate correlations between gut microbial composition and inflammatory markers in a PCOS model based on the 16S rRNA sequencing mentioned.
• Model the signaling pathway interactions involving ERβ, TGF-β1, and Smad3 based on the transcriptomics data suggested in the description.
• Compare hormonal and metabolic marker profiles between treated and untreated PCOS rats based on the described experimental design.

Strengths

• Data is openly available under a CC-BY-4.0 license.
• The study design includes multiple data modalities: transcriptomics and 16S rRNA sequencing are mentioned.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset is very small at 102.1 KB, indicating limited scope.

Provenance

Source

Cunlin Zhang via figshare.

Collection Method

Experimental data from a rat model study where PCOS was induced with letrozole and treated with sheep placental extract.

Time Range

The temporal coverage of the underlying experiment is not specified.

Freshness

Last updated 2026-04-13 04:35:50; freshness should be verified.

Geography

The spatial coverage or location of the study is not specified.