Cardiotoxicity and Echocardiographic Changes After Stem Cell Transplant: 205 Patients

Jean El Cheikh's retrospective analysis examines short-term cardiotoxic effects in 205 lymphoma and Multiple Myeloma patients undergoing autologous stem cell transplantation (ASCT) at the American University of Beirut Medical Center between 2013 and 2022. Echocardiographic parameters before ASCT were compared to those obtained 100 days post-transplant, focusing on changes in left ventricular ejection fraction (LVEF) and valvular disease incidence. Statistical analyses included paired t-tests, McNemar's test, and chi-square tests.

Use Cases

• Analyze associations between pre-existing left ventricular dysfunction and post-transplant cardiac outcomes based on the study's findings.
• Investigate gender-specific risk factors for valvular disease post-ASCT based on the reported association with male gender.
• Evaluate the impact of specific conditioning regimens (e.g., BEAM, high-dose melphalan) on early echocardiographic changes.
• Model the risk of subclinical cardiotoxicity for patients undergoing ASCT based on baseline echocardiographic parameters.

Strengths

• Includes 205 patient records from a defined single-center cohort.
• Provides specific statistical results, including a mean LVEF decline with p=0.016 and valvular abnormality prevalence changes.
• Covers a clear time range (2013-2022) and a specific follow-up window (100 days post-transplant).

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• Data may reflect geographic bias inherent to a single-center study.

Provenance

Source

American University of Beirut Medical Center (AUBMC)

Collection Method

Retrospective single-center study.

Time Range

2013 to 2022

Freshness

Last updated 2026-05-28 04:52:59; freshness should be verified.

Geography

American University of Beirut Medical Center (single-center)