Mouse Lung Inflammation Data from Short-term Cigarette Smoke and LPS Exposure Study

A 194.9 KB dataset from a 2026 figshare upload documents a study on the synergistic effects of short-term cigarette smoke and LPS in mice. The research, authored by Ziyao Liang, measured body weight changes, BALF cell counts, mRNA expression of inflammatory factors, and lung histopathology. Results indicate that brief smoke exposure sensitizes lungs to LPS-induced injury, exacerbating inflammation and oxidative stress.

Use Cases

• Modeling the synergistic effect of environmental and bacterial insults on lung inflammation based on cytokine expression data.
• Analyzing oxidative stress pathways based on markers like NOX2 and HO-1.
• Investigating early airway remodeling signaling based on expression of collagen, α-SMA, and TGF-β1.
• Correlating molecular markers with histopathological changes in lung tissue.

Strengths

• Dataset is openly licensed under CC-BY-4.0.
• Study design is explicitly detailed, including mouse strain, exposure protocol (9 cigarettes/day for 4 days), and measured indicators.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset is very small at 194.9 KB, indicating limited scope.

Provenance

Source

Ziyao Liang via figshare

Collection Method

Experimental data from a controlled animal study involving BALB/c mice, cigarette smoke exposure, and LPS instillation.

Freshness

Last updated 2026-03-19 05:19:25; freshness should be verified.