Murine Hepatic Immune Cell Profiles from Single-cell CyTOF During Aging

A 7.1 MB dataset authored by Zheng Ding and last updated in April 2026. It contains single-cell mass cytometry (CyTOF) profiling data investigating age-related changes in the murine liver immune landscape. The study identifies alterations in B cell, CD4+ T cell, and macrophage subsets.

Use Cases

• Modeling hepatic immune aging based on identified shifts in B, T, and macrophage subsets.
• Analyzing pathway enrichment in aged B cells based on described signal transduction and gene expression changes.
• Comparing proportions of immune cell populations (e.g., Igd+ B cells, CD4+ T subsets, M1 macrophages) between age groups.

Strengths

• Data is openly licensed under CC-BY-4.0, permitting reuse and redistribution.
• File size is 7.1 MB, indicating a manageable download and storage footprint.
• The description provides specific biological findings, such as the reduction of Igd+ B cells and expansion of specific CD4+ T cell subsets.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment for large-scale analyses.
• The primary data file is a DOCX document, which may require extraction or conversion for computational analysis.

Provenance

Source

figshare

Collection Method

Single-cell mass cytometry (CyTOF) profiling of murine liver samples.

Time Range

The temporal coverage of the underlying experiment is not specified.

Freshness

Last updated 2026-04-28 04:25:15; freshness should be verified.

Geography

The spatial coverage or origin of the murine models is not specified.