Single-Cell Immune Profiling of Paraneoplastic Pemphigus in a Follicular Lymphoma Patient

A longitudinal single-cell transcriptome and T cell receptor sequencing dataset from a single patient with follicular lymphoma-associated paraneoplastic pemphigus. Data includes peripheral blood mononuclear cells and bone marrow cells collected at three time points: before, during, and after treatment. The dataset was authored by Rong Wei and published on figshare under a CC-BY-4.0 license.

Use Cases

• Analyzing dynamic changes in immune cell populations based on single-cell transcriptome data collected at three treatment stages.
• Investigating T cell receptor clonal expansion based on longitudinal single-cell TCR sequencing results.
• Comparing patient immune profiles to healthy controls based on the exploratory contrasts described.
• Studying immune remodeling and DNA damage response pathways in a post-treatment context.

Strengths

• Longitudinal design with samples from three critical clinical time points.
• Multimodal single-cell data includes both transcriptome and T cell receptor sequencing.
• Dataset is 5.5 MB in size and openly available under a CC-BY-4.0 license.

Limitations

• Data is from a single patient, limiting statistical power and generalizability.
• Row and column counts are unknown, making suitability assessment difficult.
• Column-level documentation is absent; field semantics must be inferred after download.

Provenance

Source

figshare

Collection Method

Single-cell transcriptome sequencing and single-cell T cell receptor analysis performed on patient PBMCs and BMCs.

Time Range

Samples collected before, during, and after a treatment course.

Freshness

Last updated 2026-03-18 12:31:56.