Systematic Review and Meta-Analysis on Skin Cancer Risk in Alopecia Areata

A systematic review and meta-analysis evaluating the incidence of skin cancers in patients with alopecia areata. The work, published by Simonetta I. Gaumond, synthesizes evidence from eight studies, with six included in quantitative analysis. It found a statistically significant reduction in melanoma incidence associated with alopecia areata.

Use Cases

• Assessing the association between alopecia areata and melanoma risk based on the reported odds ratio
• Evaluating trends in basal cell carcinoma and squamous cell carcinoma incidence in alopecia areata patients based on the pooled estimates
• Conducting sensitivity analyses for meta-analyses based on the described leave-one-out tests
• Informing patient counseling on skin cancer risk based on the study's conclusions

Strengths

• The meta-analysis includes six studies for quantitative synthesis, providing a pooled evidence base
• Results include specific odds ratios and confidence intervals for melanoma (OR 0.58; 95% CI, 0.36-0.94), basal cell carcinoma, and squamous cell carcinoma
• Sensitivity analyses, including leave-one-out tests, were performed to confirm result stability

Limitations

• The dataset is a single 283.3 KB PDF document; the underlying tabular data or individual study records are not provided
• Column-level documentation is absent; field semantics must be inferred from the published article
• Between-study heterogeneity was reported as high (I² >80% for BCC and SCC), which may affect generalizability

Provenance

Source

Simonetta I. Gaumond via figshare

Collection Method

Systematic review and meta-analysis of records from PubMed, Embase, Scopus, and ClinicalTrials.gov

Time Range

Literature search conducted through July 2025

Freshness

Last updated 2026-05-11 04:26:13