SNH-119014: Metabolomic and ATP Response Data from β-Thalassemia Patient Erythroid Cells

A dataset from a study evaluating the novel pyruvate kinase activator SNH-119014 in cells from patients with β-thalassemia major. The data likely contains measurements of PK activity, ATP content, reactive oxygen species levels, glutathione ratios, and metabolomic profiles from 30 patients and 30 healthy controls. The dataset was authored by Qiulin Huang and last updated on 2026-04-23.

Use Cases

• Compare the efficacy of novel drug SNH-119014 versus AG-348 (mitapivat) based on PK activation metrics (AC50, Emax).
• Analyze changes in cellular energy metabolism based on ATP content measurements in treated and untreated erythroid cells.
• Investigate oxidative stress response based on reactive oxygen species (ROS) levels and reduced/oxidized glutathione (GSH/GSSG) ratios.
• Identify enriched metabolic pathways like glycolysis and the pentose phosphate pathway based on KEGG analysis results from metabolomic profiling.

Strengths

• Includes data from a controlled study with 30 β-thalassemia major patients and 30 healthy controls.
• Reports specific pharmacological metrics for SNH-119014, including an AC50 of 28.90 nM and Emax of 949.9%.
• Contains multi-faceted assessments including ATP levels, ROS, glutathione ratios, and metabolomics.

Limitations

• The dataset is described in a 581.0 KB PDF file; underlying raw data tables are not directly accessible.
• Column-level documentation is absent; field semantics must be inferred from the publication.
• Row count is unknown, which may limit suitability assessment for large-scale analysis.

Provenance

Source

figshare, authored by Qiulin Huang.

Collection Method

Laboratory study using peripheral blood and bone marrow samples from patients and healthy volunteers.

Freshness

Last updated 2026-04-23 05:35:25; freshness should be verified.