Case Report: Solid-Variant Pulmonary Adenoid Cystic Carcinoma with Pleural Metastasis

A single case report details a rare solid-variant primary pulmonary adenoid cystic carcinoma with pleural metastasis and malignant pleural effusion. The 65-year-old male patient's diagnosis was revised after immunohistochemical workup, and he received a combination therapy including tislelizumab. This case highlights a diagnostic pitfall and provides a clinical observation of immune checkpoint inhibitor-based therapy.

Use Cases

• Analyze diagnostic challenges in lung tumors based on the case's initial misclassification as squamous cell carcinoma.
• Study the efficacy of combination therapies including immune checkpoint inhibitors based on the patient's treatment regimen.
• Investigate the role of myoepithelial markers like SOX10 and c-Myb in diagnostic workup for pulmonary adenoid cystic carcinoma.
• Review clinical outcomes for advanced-stage rare cancers based on the patient's partial response and symptomatic improvement.

Strengths

• The report provides detailed clinical and pathological details for a single, exceptionally uncommon case.
• It includes specific immunohistochemical markers (SOX10, c-Myb) and a precise treatment regimen (tislelizumab, cyclophosphamide, pegylated liposomal doxorubicin, nedaplatin).

Limitations

• The dataset is a single case report (95.9 KB PDF), offering limited statistical power for broader conclusions.
• Column-level documentation is absent; field semantics must be inferred from the narrative text.
• Data may reflect temporal bias inherent to figshare, as the last update is 2026-05-18.

Provenance

Source

Suyi Guo

Freshness

Last updated 2026-05-18 04:10:40; freshness should be verified.