Mouse Dentate Gyrus Gene Expression Patterns After Denervation

28 days of gene expression data from laser-microdissected mouse dentate gyrus tissue after perforant path transection. The dataset contains whole-genome expression analysis results from the outer molecular layer and granule cell layer at 1, 3, 7, 14, and 28 days post-lesion. It was created by Jessica Schlaudraff and is licensed under CC-BY-4.0.

Use Cases

• Model temporal patterns of reactive gliosis based on the description of astrogliosis and microgliosis.
• Analyze coordinated downregulation of neurotransmission factors mentioned, such as glutamatergic signaling components.
• Study compensatory synaptic remodeling based on described upregulation of postsynaptic and dendritic membrane regulators.
• Investigate layer-specific responses (OML vs. GCL) to denervation as highlighted in the results.

Strengths

• Provides specific temporal measurements at 1, 3, 7, 14, and 28 days post-lesion.
• Includes layer-specific data from laser-microdissected outer molecular layer and granule cell layer.
• Contains quantified changes for specific genes, such as Sema3e reduced to 60% in OML.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• Dataset size is 102.8 KB, indicating a limited scope.

Provenance

Source

figshare

Collection Method

Whole-genome expression analysis performed on laser-microdissected tissue from mouse dentate gyrus following perforant path transection.

Time Range

1 to 28 days post-lesion

Freshness

Last updated 2026-05-19 05:40:43; freshness should be verified.