Murine Intratumoral T Cell Receptor Repertoire Dynamics Over 11 Days

T cell receptor repertoire data from a bilateral murine cancer model, where one tumor was removed and its pair was collected 11 days later. The dataset, authored by Pernille G. Pedersen and last updated in April 2026, compares clonotype composition and diversity metrics between time-matched and time-separated tumors. It is a 1.7 MB PDF file shared under a CC-BY-4.0 license.

Use Cases

• Tracking individual T cell clonotype changes over time based on the described clonal tracking approach.
• Comparing repertoire similarity using metrics like Morisita–Horn similarity as mentioned in the methods.
• Investigating the stability of global diversity metrics (e.g., Shannon index, Gini coefficient) during active clonal remodeling.
• Analyzing the relationship between private clonotype fractions and tumor progression as described in the results.

Strengths

• Data is derived from a controlled experimental model with paired tumor samples.
• Analysis includes multiple established metrics: Shannon diversity, Gini coefficient, and Morisita–Horn similarity.
• Dataset is openly shared under a permissive CC-BY-4.0 license.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The 1.7 MB file size suggests a relatively small dataset, potentially limiting statistical power.

Provenance

Source

figshare

Collection Method

Experimental data from a bilateral murine cancer model, with TCR repertoire analysis performed on surgically removed and later-collected tumors.

Freshness

Last updated 2026-04-23 05:27:03; freshness should be verified.