Mouse Model Data on Nicotine Enantiomer Effects on Gut-Brain Axis in Parkinson's Disease

A research document detailing a study on the stereoselective effects of S-nicotine and R-nicotine in an MPTP-induced mouse model of Parkinson's disease. The 2.3 MB DOCX file contains results on motor function, dopaminergic neuronal loss, neuroinflammation, intestinal barrier integrity, and gut microbiota composition. Authored by Ruixia Liu and last updated on 2026-05-13, it is shared under a CC-BY-4.0 license.

Use Cases

• Analyze stereoselective drug effects based on the comparison of S-nicotine and R-nicotine efficacy profiles described.
• Investigate gut-brain axis correlations based on the link between Akkermansia enrichment and improved motor function.
• Study neuroinflammatory responses based on the assessment of central and peripheral inflammation suppression.
• Model dose-dependent neuroprotection based on the different effective doses (1 mg/kg vs. 3 mg/kg) for the enantiomers.

Strengths

• The description provides specific, quantitative results, including effective doses (1 mg/kg and 3 mg/kg) and a named bacterial family (Akkermansiaceae).
• The study design is systematically described, comparing multiple endpoints: motor function, neuronal loss, inflammation, intestinal integrity, and microbiota.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The data is contained within a 2.3 MB DOCX file, which may require parsing to extract structured information.

Provenance

Source

Ruixia Liu

Collection Method

Experimental study using an MPTP-induced mouse model of Parkinson's disease.

Freshness

Last updated 2026-05-13 04:51:40; freshness should be verified.