Steroid Hormone Levels in Early Pregnancy and Birth Outcomes from a Chinese Cohort

A prospective cohort study of 364 pregnant women (30.7 ± 4.0 years) in Guangzhou, China. Nineteen steroid hormones were measured by LC-MS/MS and analyzed for associations with adverse birth outcomes. The dataset was authored by Weixiang Wu and last updated on 2026-04-20.

Use Cases

• Modeling associations between individual steroid hormone levels and birth outcomes like low birth weight or preterm birth.
• Assessing the combined effect of hormone mixtures on adverse birth outcomes using quantitative g-computation (Qgcomp).
• Investigating the relationship between specific androgens (e.g., androstenedione, testosterone) and risks like small for gestational age (SGA).
• Studying the influence of hormones like cortisol and estrone on birth length, head circumference, and gestational age.

Strengths

• Includes measurements of 19 distinct steroid hormones for each participant.
• Analyses are based on a prospective cohort of 364 pregnant women with a defined age profile.
• Employs multiple statistical models (linear regression, logistic regression, Qgcomp) to assess individual and combined effects.
• Results include specific odds ratios and confidence intervals for hormone-outcome associations.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The authors note findings are exploratory and require validation in larger cohorts.

Provenance

Source

figshare

Collection Method

Prospective cohort study with hormone measurements via LC-MS/MS.

Time Range

Early pregnancy measurements; study period not specified.

Freshness

Last updated 2026-04-20 04:11:50; freshness should be verified.

Geography

Guangzhou, China.