Stigmurin Derivatives Biofilm Disruption Data Against Pseudomonas Aeruginosa

Anne-Sophie Tareau's dataset contains results from an investigation into the anti-biofilm activity of Stigmurin and six lysine-enriched analogs against Pseudomonas aeruginosa. The data includes physicochemical characterization and measurements of effects on bacterial growth, biofilm development, and disruption of pre-established biofilms under static and dynamic conditions. The dataset was last updated on 2026-05-28.

Use Cases

• Evaluate peptide efficacy for biofilm biomass reduction based on reported 47% reduction by Stigmurin
• Compare biofilm dispersal mechanisms based on analysis of membrane fluidity and helical conformation
• Assess peptide activity under dynamic flow conditions based on reported reductions in biovolume and thickness
• Screen for non-bactericidal anti-biofilm candidates based on activity at sub-inhibitory concentrations

Strengths

• Includes results for seven distinct peptides (Stigmurin and six analogs)
• Reports specific quantitative outcomes, such as a 47% reduction in biofilm biomass by Stigmurin
• Compares peptide activity under both static and dynamic flow conditions

Limitations

• Description metadata is limited; actual data quality requires manual inspection after download
• Column-level documentation is absent; field semantics must be inferred after download
• Row count is unknown, which may limit suitability assessment

Provenance

Source

Anne-Sophie Tareau via figshare

Collection Method

Peptides were synthesized and characterized, with effects evaluated in laboratory assays.

Freshness

Last updated 2026-05-28 06:16:46; freshness should be verified