Stress and Gut Microbiota in Hepatocellular Carcinoma Progression

A research data sheet investigating the role of stress in hepatocellular carcinoma progression via the gut microbial-metabolite axis. The document, authored by Zhe Hu and last updated in May 2026, integrates clinical and preclinical models to explore the restructuring of gut microbiota and the functional role of the metabolite indole-3-propionic acid. It is shared under a CC-BY-4.0 license on figshare.

Use Cases

• Analyze stress-induced gut microbiota restructuring based on the described clinical and preclinical models
• Investigate the role of Phocaeicola vulgatus in tumor progression based on the described restoration experiments
• Study the effect of indole-3-propionic acid on endothelial JAM2 expression and macrophage crosstalk based on the described in vitro and in vivo interrogations
• Explore microbiome-based therapeutic targets for hepatocellular carcinoma based on the described translational findings

Strengths

• The description provides a detailed mechanistic pathway linking stress, gut microbiota, and tumor progression
• The data sheet is shared under a permissive CC-BY-4.0 license, allowing for reuse

Limitations

• The dataset consists of a single 335.6 KB DOCX file, suggesting limited scope and likely no raw data tables
• Column-level documentation is absent; field semantics must be inferred from the document text
• Row count is unknown, which may limit suitability assessment for quantitative analysis

Provenance

Source

figshare

Collection Method

Integrates clinical and preclinical models, with in vitro and in vivo interrogations.

Freshness

Last updated 2026-05-12 16:09:59