Meta-Analysis of Brain Alterations in Depression with Alzheimer's and MCI

A multimodal coordinate-based meta-analysis synthesizes findings from 30 neuroimaging studies involving 1,973 participants. It explores structural and functional brain alterations in Alzheimer's Disease and Mild Cognitive Impairment patients with depression. The analysis identifies decreased gray matter volume in the right hippocampus and altered neural activity in frontal and temporal gyri.

Use Cases

• Compare gray matter volume (GMV) abnormalities in the hippocampus between patient groups with and without depression.
• Analyze neural activity differences in the superior frontal gyrus (SFG) and inferior temporal gyrus (ITG) across ADD, MCID, ADND, and MCIND subgroups.
• Validate neuroimaging findings on depression correlates in cognitive disorders using the synthesized results from 30 studies.

Strengths

• Aggregates data from 30 individual neuroimaging studies, providing a synthesized evidence base.
• Includes a total participant pool of 1,973 individuals across four clinical subgroups.
• Employs a multimodal analysis approach, examining both structural (GMV) and functional neural activity alterations.
• Covers a literature search time range from December 1995 to December 2025.

Limitations

• The dataset is a 159.5 KB DOCX file containing a meta-analysis report, not the underlying raw neuroimaging or participant-level data.
• Findings are derived from coordinate-based meta-analysis (ALE), which summarizes reported brain region coordinates rather than original image files.
• The scope is limited to the specific research question of depression in AD/MCI, not a general neuroimaging repository.

Provenance

Source

figshare, authored by Yang Du.

Collection Method

Coordinate-based meta-analysis (Activation Likelihood Estimate) of neuroimaging studies identified via systematic search of PubMed, Embase, PsycINFO, and Cochrane Library.

Time Range

Literature search covers studies published from December 1995 to December 2025.

Freshness

Last updated in March 2026.

Geography

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