Review of 158 Phenanthrenes from Dendrobium Orchids (1987–2025)

A 2026 literature review systematically analyzes 158 naturally occurring phenanthrene compounds isolated from 53 Dendrobium orchid taxa between 1987 and 2025. Authored by Jie Jian, the document summarizes pharmacopoeial records and bioactivity data, noting that 64 compounds have been evaluated in assays. The review highlights structural diversity and reported therapeutic potentials.

Use Cases

• Identify candidate compounds for drug discovery based on reported anti-tumor, anti-inflammatory, and antioxidant activities.
• Study the structural diversity of natural phenanthrenes based on the classification into simple phenanthrenes, dihydrophenanthrenes, and dimers.
• Assess the state of preclinical validation for traditional medicinal compounds based on the reported ratio of in vitro to in vivo studies.
• Analyze research trends and gaps in natural product studies based on the literature survey spanning nearly four decades.

Strengths

• Systematically reviews 158 specific compounds from 53 Dendrobium taxa, providing a quantitative foundation.
• Summarizes bioactivity data for 64 compounds (40.5% of the total), detailing assay endpoints.
• Explicitly notes the scope of validation, stating only 4 compounds (6.2%) demonstrate in vivo efficacy.

Limitations

• The document is a review article (3.7 MB DOCX), not a primary dataset; data must be extracted manually.
• Row count and column-level documentation are absent; field semantics must be inferred from the text.
• Data may reflect publication bias inherent to the literature sources surveyed.

Provenance

Source

Jie Jian via figshare.

Collection Method

Literature review of international and Chinese databases (PubMed, Web of Science, SciFinder, CNKI).

Time Range

1987 to 2025

Freshness

Last updated 2026-05-15 05:52:23; freshness should be verified.