Data Sheet 1_Study of the temperature-related factors that activate the NLRP3 inflammasome

Xinjiang-focused research investigating the molecular links between temperature adaptation and pathogenicity in the fungus Trichophyton schoenleinii. The dataset, authored by Kaidiliya Aimilajiang and last updated in May 2026, contains a 586.2 KB PDF detailing transcriptome sequencing, bioinformatics analysis, and cellular assays on THP-1 cells. It identifies a key temperature regulatory factor and explores activation mechanisms of the NLRP3 inflammasome via ROS, cathepsin, and potassium efflux.

Use Cases

• Identifying differentially expressed genes under heat stress based on transcriptome sequencing results.
• Studying the role of ROS, cathepsin B, and potassium efflux in NLRP3 inflammasome activation based on the described cellular inhibition assays.
• Analyzing the function of the identified temperature regulatory factor TRINITY_DN3793_c0_g1 based on gene silencing experiments.
• Investigating the expression of cytokines IL-1β and IL-18 in response to fungal infection based on the described detection methods.

Strengths

• Includes specific experimental details such as heat stress at 42°C, 37°C, and a 27°C control.
• Identifies a concrete gene target, TRINITY_DN3793_c0_g1, as a key temperature regulatory factor.
• Describes a clear methodological pipeline from transcriptomics to cellular validation using inhibitors and RNA interference.

Limitations

• The dataset is a single 586.2 KB PDF document, which is a very small and limited data scope.
• Row count and column-level data are unknown; the actual structured data requires extraction from the PDF.
• Description metadata is limited; actual data quality requires manual inspection after download.

Provenance

Source

figshare

Collection Method

Transcriptome sequencing and bioinformatics analysis of Trichophyton schoenleinii strain 30076 under heat stress, followed by cellular assays on THP-1 cells.

Time Range

null

Freshness

Last updated 2026-05-20 05:44:25; freshness should be verified.

Geography

Research is focused on elucidating the pathogenesis of tinea capitis in Xinjiang.