Case Report: Autoimmune Hepatitis and Liver Failure Following PD-1 Immunotherapy

A figshare-hosted case report authored by Yu Peng, last updated on 2026-04-28. The document details the clinical management of a 58-year-old male patient with nasopharyngeal carcinoma who developed severe autoimmune hepatitis and subacute liver failure after receiving tislelizumab (an anti-PD-1 antibody) combined with chemotherapy. It describes the diagnostic and therapeutic interventions, including high-dose corticosteroids, mycophenolate mofetil, and artificial liver support.

Use Cases

• Analyze clinical progression and management of severe ICI-induced hepatotoxicity based on the detailed case narrative.
• Study the efficacy of multimodal immunosuppressive therapy combined with artificial liver support for liver failure as described in the report.
• Review diagnostic criteria and grading guidelines (e.g., CSCO) for ICI-related liver injury referenced in the conclusion.
• Examine patient outcomes and recovery timelines following aggressive intervention for immune-mediated liver failure.

Strengths

• Provides a detailed, real-world clinical narrative of a severe adverse event, including specific treatments like tislelizumab, methylprednisolone, and plasma exchange.
• Includes a clear temporal sequence of the patient's deterioration, transfer, intervention, and recovery.
• Released under a permissive CC-BY-4.0 license, allowing for reuse and redistribution.

Limitations

• Description metadata is limited; actual data quality requires manual inspection after download.
• Row count is unknown, which may limit suitability assessment.
• The dataset is a single case report (739.0 KB), representing a very limited scope and sample size.

Provenance

Source

figshare, author Yu Peng.

Collection Method

Likely a documented clinical case from medical practice.

Time Range

The clinical events described likely occurred prior to the report's publication in 2026.

Freshness

Last updated 2026-04-28 04:29:03; freshness should be verified.

Geography

Geography is not specified in the provided description.