Survival Outcomes and Biomarkers in Metastatic Pancreatic Cancer Third-Line Therapy

Data from the Slovak Pancreas Registry includes 95 patients with metastatic pancreatic ductal adenocarcinoma treated with third-line systemic therapy. The study analyzes survival outcomes and the prognostic value of nutritional and inflammatory markers, such as the Prognostic Nutritional Index and Glasgow Prognostic Score. It reports a median overall survival of 5.55 months and a median progression-free survival of 3.29 months.

Use Cases

• Analyze the association between Prognostic Nutritional Index (PNI) values and overall survival (OS) or progression-free survival (PFS) using Kaplan-Meier analysis.
• Evaluate the impact of Glasgow Prognostic Score (GPS) on survival outcomes in patients receiving third-line therapies like FOLFOX/CAPOX or nanoliposomal irinotecan.
• Investigate the statistical significance of inflammatory markers like NLR, SIRI, SII, and CRP on patient survival outcomes from the Slovak registry data.
• Model survival probability based on baseline patient parameters, including ECOG status and specific chemotherapy regimens.

Strengths

• Includes 95 patient records from a clinical registry spanning 13 hospitals, providing a multi-center perspective.
• Reports specific survival metrics, including a median OS of 5.55 months and median PFS of 3.29 months, with statistical significance for key biomarkers.
• Analyzes multiple established prognostic scores (PNI, GPS, NLR, SIRI, SII, CRP) for their association with survival outcomes.

Limitations

• The sample size of 95 patients is relatively small for robust multivariate analysis or subgroup comparisons.
• Data is from a specific national registry (Slovak Pancreas Registry), which may limit generalizability to other populations.
• The primary data is embedded in a DOCX file (779.3 KB), which may require extraction and structuring for computational analysis.

Provenance

Source

Slovak Pancreas Registry, data collected from 13 hospitals.

Collection Method

Retrospective and prospective analysis of patient records.

Freshness

Last updated on 2026-03-24.

Geography

Slovakia