Mouse Proteomic Response to Echinostoma caproni Infection at 4 Weeks

A proteomic analysis of ileal epithelial cells from male ICR mice infected with the helminth Echinostoma caproni, collected 4 weeks post-infection. The dataset, authored by Emma Fiallos and last updated on 2026-04-21, contains differential protein expression data from LC-MS/MS analysis. It reveals infection-induced changes in mitochondrial function, metabolism, and immune response pathways.

Use Cases

• Identify biomarkers of host susceptibility based on upregulated proteins involved in oxidative phosphorylation and purine metabolism.
• Study epithelial barrier dysfunction based on downregulated proteins linked to tight junction maintenance and vesicular trafficking.
• Investigate immune response skewing based on the overexpression of antimicrobial peptides and reduction of eosinophil/neutrophil effectors.
• Model metabolic reprogramming during chronic infection based on changes in fatty acid β-oxidation and nucleotide binding proteins.

Strengths

• Proteomic data generated using LC-MS/MS with DDA and SWATH methods, as described.
• Analysis focuses on a specific time point (4 weeks post-infection) in a controlled mouse model.
• Dataset is openly available under a CC-BY-4.0 license.

Limitations

• The dataset is very small (21.2 KB), suggesting limited scope or summary-level data.
• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment for large-scale analyses.

Provenance

Source

figshare, author Emma Fiallos.

Collection Method

Proteins were extracted from isolated ileal epithelial cells of infected mice for LC-MS/MS analysis.

Time Range

Samples collected 4 weeks post-infection.

Freshness

Last updated 2026-04-21 04:23:08; freshness should be verified.