Synaptic Alterations Preceding Axonal Loss in Wolfram Syndrome Mouse Model

A 1.3 MB PDF data sheet authored by Venu Gurram, last updated on 2026-05-22. It describes confocal microscopy analysis of retinal and optic nerve histology in Wfs1 knockout mice at 4 and 7 months of age. The study identifies progressive synaptic alterations in the inner plexiform layer as the earliest detectable phenotype associated with vision loss.

Use Cases

• Analyze the timeline of synaptic versus axonal degeneration based on the described 4- and 7-month age points.
• Investigate the role of presynaptic compartment failure in early vision loss as described in the results.
• Validate in vivo synaptic abnormalities in WFS1-deficient models based on the comparison to prior in vitro organoid studies.
• Identify potential therapeutic targets for vision preservation based on the conclusion regarding early synaptic changes.

Strengths

• Data is openly licensed under CC-BY-4.0.
• The study provides a specific temporal analysis at 4 and 7 months of age.
• Focuses on a defined, rare disease model (Wolfram syndrome mouse model).

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset is a 1.3 MB PDF, likely containing summary data rather than raw experimental records.

Provenance

Source

figshare

Collection Method

Confocal microscopy examination of retinal and optic nerve histology.

Time Range

Mouse ages of 4 and 7 months.

Freshness

Last updated 2026-05-22 05:33:42; freshness should be verified.