Synaptosome Calcium Handling and Respiration in Motor Neuron Disease

Sean D. Morrison's dataset contains functional measurements from synaptosomes isolated from cryopreserved human motor cortex and mouse models. The data likely includes depolarization-evoked calcium influx amplitudes and Complex IV-driven oxygen consumption rates, comparing Motor Neuron Disease (MND) samples to controls. The dataset was last updated on May 22, 2026.

Use Cases

• Compare depolarization-evoked calcium influx amplitudes between MND and control synaptosomes.
• Analyze Complex IV-driven oxygen consumption rates in synaptosome-enriched fractions.
• Correlate calcium influx response amplitudes with donor variables like post-mortem interval.
• Investigate protein-to-oxygen consumption rate relationships in synaptosome and free-mitochondrial fractions.

Strengths

• Data is derived from paired fresh and frozen mouse cortex as well as cryopreserved human motor cortex, providing a comparative basis.
• The dataset includes measurements from neuropathologically confirmed MND motor cortex and the hSOD1G93A mouse model.
• License is CC-BY-4.0, facilitating open reuse.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The dataset is 1.4 MB, suggesting a relatively small scale.

Provenance

Source

figshare

Collection Method

Functional assays (Seahorse respiratory assays, calcium mobilization measurements) performed on synaptosome isolates.

Freshness

Last updated 2026-05-22 05:33:41; freshness should be verified.