Data Sheet 1: Experimental Results on Liver Fibrosis Treatment in Rats

A research document from figshare, authored by Mengyao Zong and last updated in April 2026, details a study on combination therapy for cholestatic liver fibrosis. The 6.7 MB document describes in vitro and in vivo experiments using a rat model, evaluating serum biochemistry, liver histopathology, and molecular mechanisms. The data is shared under a CC-BY-4.0 license.

Use Cases

• Analyzing the synergistic effects of drug and gene therapy based on the described combination of total astragalus saponins and AAV8.Numb-Exon3.
• Studying hepatic progenitor cell differentiation fate based on the described modulation of HPCs towards hepatocytes versus cholangiocytes.
• Investigating molecular mechanisms in liver fibrosis based on the described analysis of the Notch signaling pathway and ductular reaction.
• Benchmarking anti-fibrotic treatments based on the described metrics of hepatic hydroxyproline content, collagen deposition, and liver regeneration.

Strengths

• Document is 6.7 MB, suggesting detailed textual content.
• Specific experimental methods are described, including bile duct ligation rat models and WB-F344 cell line work.
• License is clearly stated as CC-BY-4.0, permitting reuse with attribution.

Limitations

• The primary data format is a DOCX file, which may require parsing to extract structured information.
• Row count and column-level documentation are absent; field semantics must be inferred after download.
• Data is derived from a specific animal model, which may limit direct translation to human clinical contexts.

Provenance

Source

figshare, author Mengyao Zong.

Collection Method

Experimental study involving rat models of cholestatic liver fibrosis and in vitro cell culture.

Freshness

Last updated 2026-04-23 05:35:22; freshness should be verified.