Synthesis and Antiviral Activity of 3,5-Disubstituted Isothiazolo[4,3-b]pyridines

Ling-Jie Gao published a research document on figshare in May 2026 describing a focused library of 3,5-disubstituted isothiazolo[4,3-b]pyridine compounds. The document details their synthesis, structure-activity relationships, and evaluation as PIKfyve inhibitors with antiviral activity against SARS-CoV-2. The dataset is a 5.2 MB DOCX file available under a CC-BY-4.0 license.

Use Cases

• Analyzing structure-activity relationships (SAR) based on the described 3,5-disubstituted chemical library.
• Training models to predict PIKfyve inhibition potency based on synthetic compound features mentioned in the description.
• Studying binding modes of isothiazolo[4,3-b]pyridine derivatives to the ATP-binding site as described via molecular modeling.
• Screening for potential antiviral candidates against SARS-CoV-2 based on the reported low μM activity.

Strengths

• Document describes compounds with potent PIKfyve inhibition in the low nM range.
• Compounds demonstrated antiviral activity against SARS-CoV-2 in the low μM range.
• Data is openly available under a CC-BY-4.0 license.

Limitations

• Row count and column-level documentation are unknown, limiting suitability assessment.
• The primary data format is a DOCX document, which may require parsing to extract structured information.
• Description metadata is limited; actual data quality requires manual inspection after download.

Provenance

Source

Ling-Jie Gao via figshare.

Collection Method

Synthetic chemistry and biochemical assays described in the research document.

Time Range

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Freshness

Last updated 2026-05-08 05:40:35; freshness should be verified.

Geography

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