Plasma Proteomics and Organ Aging in a Korean Alzheimer's Cohort

A Korean cohort study quantifies 7,288 plasma proteins from 40 Alzheimer's and non-Alzheimer's subjects. The dataset includes measurements of amyloid-beta oligomerization tendency (OAβT), amyloid PET status, and aging signatures for 11 organs. It was authored by Hyunjung Oh to investigate systemic proteomic changes linked to early Alzheimer's pathology.

Use Cases

• Analyze correlations between the 7,288 quantified plasma proteins and amyloid-beta oligomerization tendency (OAβT) values to identify potential blood-based biomarkers.
• Compare proteomic signatures between groups defined by amyloid PET status and OAβT values to investigate OAβT-PET mismatched cases.
• Assess associations between organ aging signatures for 11 organs and OAβT values to explore systemic aging factors in Alzheimer's disease.
• Investigate pharmacological influences by comparing OAβT-correlated proteins with a database of drug-induced proteomic changes.

Strengths

• Quantifies 7,288 plasma proteins per subject using aptamer-based proteomics.
• Includes multi-modal data: OAβT values, amyloid PET status, and organ aging signatures for 11 organs.
• Published under a permissive CC BY 4.0 license for open reuse.

Limitations

• Small sample size of 40 subjects limits statistical power and generalizability.
• Data is cross-sectional, preventing analysis of temporal or causal relationships.
• The 385.0 KB file size indicates a limited scope, likely containing summary or processed results rather than raw proteomic data.

Provenance

Source

Figshare, authored by Hyunjung Oh.

Collection Method

Aptamer-based proteomic quantification of plasma samples from a defined clinical cohort.

Time Range

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Freshness

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Geography

South Korea