SBC8803: Zebrafish Gut-Brain Multi-Omics Data for Anxiolytic Psychobiotic Investigation

A 4-week study of adult male AB-strain zebrafish fed heat-killed Lactobacillus brevis SBC8803. The dataset includes behavioral test results, brain RNA sequencing, and 16S rRNA amplicon sequencing of intestinal contents, collected by Azusa Kubota and last updated in May 2026. It supports integrative multi-omics analyses of gut-brain interactions related to anxiety.

Use Cases

• Identify differentially expressed genes in brain serotonin and oxytocin signaling pathways based on transcriptomic profiling.
• Analyze shifts in predicted gut microbiome functions related to lipid and vitamin metabolism, such as riboflavin and tryptophan pathways.
• Perform integrative correlation analysis to explore links between microbial metabolic pathways and brain signaling, like the vitamin B–serotonin–anti-inflammatory axis.
• Investigate innate gut-brain coordination independent of treatment, such as coupling between brain arachidonic acid and gut histidine metabolism.

Strengths

• Integrates three data modalities: behavioral assays, brain transcriptomics, and gut microbiome sequencing from a controlled 4-week experiment.
• Data is structured for multi-omics integration, specifically mentioning GSVA and DIABLO-based analysis.
• Dataset is openly licensed under CC-BY-4.0, facilitating reuse and sharing.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment for specific analytical needs.
• The dataset is specific to adult male AB-strain zebrafish, which may limit generalizability to other models or sexes.

Provenance

Source

figshare, authored by Azusa Kubota.

Collection Method

Experimental data from zebrafish fed a diet containing heat-killed SBC8803, with behavioral testing, RNA-seq, and 16S rRNA sequencing.

Time Range

Study duration was 4 weeks; specific collection dates are not provided.

Freshness

Last updated 2026-05-21 05:35:21; freshness should be verified.