Pathogen Detection in Pediatric ICU Pneumonia Patients Using Targeted NGS, 2021-2024

Clinical data from 344 children with severe pneumonia admitted to a Pediatric Intensive Care Unit in Guangxi, China, between June 2021 and December 2024. The dataset compares pathogen detection results from targeted next-generation sequencing (tNGS) and conventional microbiological tests, identifying 86 pathogens and antimicrobial resistance genes. It was created by Ning Zhu and shared under a CC-BY-4.0 license.

Use Cases

• Compare the diagnostic sensitivity of tNGS versus conventional tests based on the reported detection rates (99.71% vs. 49.71%).
• Analyze patterns of co-infection and pathogen prevalence based on the described rates of multiple infections and the four most common pathogens.
• Study antimicrobial resistance gene profiles in pediatric pneumonia based on the reported mecA, bla_CTX-M, bla_NDM, and A2063G mutation findings.

Strengths

• Includes results from 344 patient cases, providing a substantial clinical cohort.
• Reports specific detection rates (99.71% for tNGS) and co-infection prevalence (84.30% multiple pathogens).
• Identifies 86 distinct pathogens and quantifies antimicrobial resistance gene presence (e.g., in 10.17% of cases).

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• Data reflects a single geographic and temporal context, which may limit generalizability.

Provenance

Source

Maternal and Child Health Hospital in Guangxi Province, China.

Collection Method

Targeted next-generation sequencing (tNGS) and conventional microbiological tests performed on patient samples.

Time Range

June 2021 to December 2024.

Freshness

Last updated 2026-04-28 05:27:33; freshness should be verified.

Geography

Guangxi Province, China.