Targeting Histamine H4 Receptor in a Murine Breast Cancer Model

A research article published on figshare by Ramiro Vázquez, last updated on 2026-04-21. The study investigates the role of the histamine H4 receptor in tumor progression and immune response using a 4T1 cell line murine model of breast cancer. The file is a 473.7 KB PDF containing the full research paper.

Use Cases

• Analyzing the role of histamine H4 receptor blockade on tumor cell proliferation based on described in vitro assays.
• Studying immune cell recruitment in the tumor microenvironment based on described CD8+ cell measurements.
• Investigating metabolic alterations in tumor-derived cells based on described lactate release and energy metabolism findings.

Strengths

• The dataset is a full research paper with a detailed methodology section.
• The study uses a specific murine model (4T1 cell line) and antagonist (JNJ777120).
• The file is openly available under a CC-BY-4.0 license.

Limitations

• The dataset is a single PDF document, not a structured data table.
• Row count and column-level documentation are absent; data must be extracted manually.
• The description metadata is limited to the paper's abstract; actual data quality requires manual inspection.

Provenance

Source

figshare

Collection Method

Experimental research using a murine model and in vitro assays.

Freshness

Last updated 2026-04-21 05:20:24