Cytokine Profiles and Nanotrap Efficacy in Sepsis Patient Plasma

Plasma from 20 individual sepsis patients was used to validate the cytokine removal efficacy of engineered telodendrimer nanotrap resins. The study correlates patient cytokine levels with clinical SOFA and SII scores, identifying three lead nanotrap formulations with distinct cytokine binding profiles. Data is contained within a 3.8 MB DOCX file authored by Jennifer M. Messina.

Use Cases

• Analyze correlations between patient cytokine profiles and clinical SOFA or SII scores.
• Compare the cytokine clearance efficacy of three lead nanotrap resins against a commercial MG250 resin.
• Study the selective binding profiles of nanotraps for positively charged, negatively charged, or universal cytokine removal.
• Investigate the relationship between total cytokine burden in patient plasma and predicted mortality risk.

Strengths

• Data is derived from validation using 20 individual sepsis patient plasma samples.
• Includes clinical correlation metrics such as SOFA and SII scores.
• Results compare three distinct nanotrap formulations and a commercial resin.

Limitations

• The dataset is small, consisting of a single 3.8 MB DOCX file with no explicit tabular structure.
• Data is embedded in a research paper format, requiring extraction for computational analysis.
• Sample size is limited to 20 patients from a specific abdominal sepsis cohort.

Provenance

Source

figshare, authored by Jennifer M. Messina.

Collection Method

Plasma characterization and nanotrap resin screening from patients with abdominal sepsis.

Freshness

Last updated on March 25, 2026.