Temporal Transcriptional Dynamics in a Cutaneous Leishmaniasis Mouse Model

A longitudinal transcriptomic analysis of host responses to Leishmania braziliensis infection in a BALB/c mouse model. The dataset includes bulk RNA sequencing data from skin lesions and draining lymph nodes at six time points from 2 hours to 77 days post-infection. It was authored by Jessica Lobo-Silva and published on figshare in May 2026.

Use Cases

• Identify host-directed therapeutic targets based on conserved non-coding RNAs and epigenetic regulators.
• Analyze stage-specific gene expression modules associated with innate response, tissue damage, and skin remodeling.
• Compare inflammatory pathway activation between mouse models and human disease based on the described 77% recapitulation.
• Study temporal dynamics of macrophage polarization and nitric oxide metabolism genes during infection and healing.

Strengths

• Longitudinal design with data from six distinct time points spanning from 2 hours to 77 days post-infection.
• Cross-species comparison identified 16 conserved microRNAs and 12 shared epigenetic regulators.
• Mouse lesions recapitulated 77% of inflammatory pathways described in human cutaneous leishmaniasis.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• Data is contained within a PDF file, which may require extraction and structuring for computational analysis.

Provenance

Source

figshare

Collection Method

Bulk RNA sequencing performed on samples from a BALB/c ear dermal mouse model infected with L. braziliensis.

Time Range

Data collected at 2, 6, and 48 hours and at 14, 35, and 77 days post-infection.

Freshness

Last updated 2026-05-12 04:20:21; freshness should be verified.

Geography

Laboratory mouse model; specific geographic origin of the study is not stated.