Scoping Review on Testosterone and Sepsis Immunometabolism, 2015-2025

Mateusz Szczupak's scoping review synthesizes evidence on testosterone's role in sepsis immunometabolism. The review includes 13 studies published between 2015 and 2025, sourced from PubMed, Scopus, Web of Science, Cochrane Library, and EBSCO. It concludes that testosterone deficiency correlates with higher disease severity and mortality, but current evidence does not support routine androgen therapy.

Use Cases

• Systematically map evidence on testosterone levels in sepsis based on the review's aim
• Analyze associations between testosterone deficiency and disease severity (SOFA/APACHE II scores) based on reported results
• Evaluate the therapeutic implications of androgen receptor pathway modulation based on the review's conclusions

Strengths

• Follows Joanna Briggs Institute methodology and PRISMA-ScR guidelines, indicating a structured review process
• Searches five major databases (PubMed, Scopus, Web of Science, Cochrane Library, EBSCO) for comprehensive evidence gathering
• Includes studies from 2015 to 2025, covering a 10-year period of recent research

Limitations

• The dataset is a single PDF document (118.0 KB), limiting direct computational analysis of the underlying data
• Row count and column-level documentation are unknown, requiring manual inspection of the review text
• The dataset's conclusions are based on only 13 included studies, indicating a limited evidence base

Provenance

Source

Mateusz Szczupak

Collection Method

Scoping review conducted according to Joanna Briggs Institute methodology and PRISMA-ScR guidelines.

Time Range

2015-2025

Freshness

Last updated 2026-05-07 04:44:23