Mouse Study on 2R,3R-Butanediol Effects on Weight Gain and Metabolites

Sunil Veeravalli's dataset contains results from a study investigating the effects of 2,3-butanediol isomers on mice fed a fat-enriched diet. The data includes measurements of weight, plasma and liver metabolite concentrations, and gut microbiota composition. The study identified 2R,3R-butanediol as an effective agent for preventing weight gain and lowering plasma glucose.

Use Cases

• Identify anti-obesogenic compounds based on weight and plasma glucose measurements.
• Investigate the relationship between specific liver metabolites and weight control based on concentrations of indolepropionate and other compounds.
• Analyze the impact of dietary supplements on gut microbiota composition based on changes in Bacteroidota and Actinomycetota phyla.
• Compare the efficacy of different stereoisomers of a compound based on treatment groups with 2R,3R-, 2S,3S-, and meso-2,3-butanediol.

Strengths

• Dataset includes 693 identified liver metabolites, providing a detailed metabolic profile.
• Study design includes multiple treatment groups (different isomers) and a control group fed a 16% fat-enriched diet.
• Analysis spans multiple data types: weight, plasma metabolites, liver metabolites, and gut microbiota composition.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The dataset is small (112.3 KB), indicating limited scope.

Provenance

Source

Sunil Veeravalli

Collection Method

Experimental study where mice were fed standard or fat-enriched diets and treated with butanediol isomers, followed by analysis of weight, metabolites, and microbiota.

Freshness

Last updated 2026-05-25 09:59:35; freshness should be verified.