Systematic Review with Multi-Omics Corroboration on Non-IgE Cow's Milk Allergy

A 2026 systematic review synthesizing evidence from 39 studies of infants aged 0–3 years with physician-confirmed non-IgE-mediated cow's milk allergy. The review, authored by Wei Kong and published on figshare, includes an integrative analysis of publicly available single-cell RNA sequencing datasets. It investigates the AhR–TLR4 axis, gut dysbiosis, and potential biomarkers and interventions.

Use Cases

• Validate the Bifidobacterium/Enterobacteriaceae (B/E) ratio as a predictive biomarker for persistent allergy based on the reported HR and AUC values.
• Investigate the AhR–TLR4 mechanistic pathway in intestinal epithelial cells based on the described dysbiosis signature and scRNA-seq findings.
• Assess the potential of synbiotic interventions for symptom resolution based on the reported 67% improvement associated with LGG + HMOs.

Strengths

• Evidence synthesis follows PRISMA guidelines, incorporating 39 studies.
• Includes multi-omics corroboration via analysis of public scRNA-seq datasets.
• Reports specific predictive metrics (HR=1.9, AUC=0.82 for B/E ratio).

Limitations

• The dataset is a 137.4 KB PDF document, representing a limited scope review rather than primary data.
• Row count and column-level documentation for any underlying data are absent.
• Description metadata is limited; actual data quality requires manual inspection after download.

Provenance

Source

figshare

Collection Method

Systematic review with integrated analysis of public datasets.

Time Range

Studies focus on infants aged 0–3 years.

Freshness

Last updated 2026-04-14 05:39:06.

Geography

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