Maternal Thyroid Hormone Ratio and Neonatal Outcomes in a Retrospective Cohort

Xiaoyu Chen's retrospective cohort study analyzes data from 797 mother-infant pairs to investigate the association between the maternal free triiodothyronine to free thyroxine ratio in early pregnancy and adverse neonatal outcomes. The study, last updated in May 2026, employed multivariable logistic regression and restricted cubic spline modeling. Results demonstrated a non-linear J-shaped association, with the highest quartile of the ratio linked to increased risks of neonatal anemia, patent ductus arteriosus, jaundice, and myocardial injury.

Use Cases

• Modeling the non-linear association between maternal thyroid hormone ratios and composite neonatal adverse outcomes based on the described J-shaped pattern.
• Investigating subgroup-specific risks for nulliparous women, mothers with normal BMI, and female neonates as indicated in the results.
• Validating the FT3/FT4 ratio as a potential clinical indicator of neonatal risk independent of traditional obstetric factors.
• Training predictive models for neonatal complications using early-pregnancy thyroid function markers.

Strengths

• Dataset includes 797 mother-infant pairs, providing a substantive cohort size.
• Analysis adjusted for confounders including maternal age, body mass index, and gestational age.
• Study employed both linear and non-linear (restricted cubic spline) modeling techniques.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The 558.2 KB file size suggests the dataset is small in scale.

Provenance

Source

Xiaoyu Chen

Collection Method

Retrospective cohort study analyzing clinical data from eligible mother-infant pairs.

Freshness

Last updated 2026-05-12 04:19:36; freshness should be verified.